Ethyl bromoacetate → HCID 67549574, compound

HRID 1786250Notes

Reaction equation

HRID 1786250 reaction equation
[CH3:1][CH:2]1[C:6](=[O:7])[NH:5][N:4]=[CH:3]1.Br[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].C(=O)([O-])[O-].[K+].[K+].CCCCCCC>C(OCC)(=O)C>[CH2:13]([O:12][C:10](=[O:11])[CH2:9][N:4]1[CH:3]=[C:2]([CH3:1])[C:6](=[O:7])[NH:5]1)[CH3:14]

Participants

6

Reactant 4

HCID 7748Ethyl bromoacetateHCID 8900HeptaneHCID 11430Potassium CarbonateHCID 989354-Methyl-2-pyrazolin-5-one

Product 1

HCID 67549574HCID 67549574, compoundYield 16%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

As described for example 320a, 4-methyl-2-pyrazolin-5-one was reacted with ethyl bromoacetate and potassium carbonate. Extractive workup followed by chromatography (SiO2, heptane:ethyl acetate=100:0 to 50:50) afforded the title compound as a white solid (yield: 16%). MS: m/e=185.0 [M+H]+.

Sources & evidence

ORD record
ord-3aad6f459cfe4326ad8c19288ce80229
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

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