反应详情

A mixture of 3-bromo-5-methylphenol [(40.7 g, 218 mmol) J. Amer. Chem. Soc., 2003, 125, 7792)], benzyl bromide (28.6 mL, 239 mmol) and potassium carbonate (90.2 g, 653 mmol) in acetone (1 L) was heated under reflux for 2 hours. The cooled reaction mixture was then acidified with 2M hydrochloric acid and the aqueous layer was extracted with ethyl acetate. The organic solution was washed with brine (×3), dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a red oil in quantitative yield.

1. temperatureunder reflux for 2 hours
2. customThe cooled reaction mixture
3. extractionthe aqueous layer was extracted with ethyl acetate
4. washThe organic solution was washed with brine (×3)
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated in vacuo