Water → HCID 86610265, compound

HRID 1787934Notes

Reaction equation

HRID 1787934 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][O:15][C:16]2[CH:25]=[C:24]([O:26][CH2:27][CH2:28][F:29])[CH:23]=[CH:22][C:17]=2[C:18]([O:20]C)=[O:19])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O[Li].O.O>C1COCC1>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][O:15][C:16]2[CH:25]=[C:24]([O:26][CH2:27][CH2:28][F:29])[CH:23]=[CH:22][C:17]=2[C:18]([OH:20])=[O:19])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 86610263HCID 86610263, compound

Product 1

HCID 86610265HCID 86610265, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Using a procedure similar to that of Example 26-C, the ester is hydrolyzed using LiOH.H2O (1.50 g, 2.2 equivalents), water (20 mL) and THF (60 mL) to afford the acid (2.93 g, 59% for the two steps).

Workup

  1. customto afford the acid (2.93 g, 59% for the two steps)

Sources & evidence

ORD record
ord-02293026a49c475ba7ec60af6f3d7760
Source dataset
uspto-grants-2009_03
Patent number
US07511066B2

Reaction notes

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