1,3-Dibromopropane → HCID 5276067, compound

HRID 1788444Notes

Reaction equation

HRID 1788444 reaction equation
[Cl:1][C:2]1[CH:46]=[CH:45][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:22]5[N:26]([CH:27]6[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]6)[C:25]6[CH:33]=[CH:34][C:35]([C:37]([OH:39])=[O:38])=[CH:36][C:24]=6[N:23]=5)[CH:18]=4)[N:13]=3)=[CH:10][C:9]([O:40][CH2:41][CH2:42]OC)=[CH:8][CH:7]=2)=[CH:4][CH:3]=1.Br[CH2:48][CH2:49][CH2:50]Br.BrCCOC.[NH:57]1[CH2:61]CC[CH2:58]1>>[Cl:1][C:2]1[CH:46]=[CH:45][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:22]5[N:26]([CH:27]6[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]6)[C:25]6[CH:33]=[CH:34][C:35]([C:37]([OH:39])=[O:38])=[CH:36][C:24]=6[N:23]=5)[CH:18]=4)[N:13]=3)=[CH:10][C:9]([O:40][CH2:41][CH2:42][CH2:58][N:57]3[CH2:61][CH2:50][CH2:49][CH2:48]3)=[CH:8][CH:7]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 80011,3-DibromopropaneHCID 31268PyrrolidineHCID 809722-Bromoethyl methyl etherHCID 5276094HCID 5276094, compound

Product 1

HCID 5276067HCID 5276067, compound

Procedure

The title compound was synthesized as described for Compound 475, except 1,3-dibromopropane was used for alkylation instead of 1-bromo-2-methoxy ethane. The resulting 3-bromopropyl derivative was treated in situ with an excess of pyrrolidine to give the final product.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-a662eb771b9d4c87905f3eacaa250c08
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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