Dimethyl Sulfoxide → HCID 13768078, compound

HRID 1789373Notes

Reaction equation

HRID 1789373 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][S:15][C:16]3[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=3[CH2:18][OH:19])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C(Cl)=O.CS(C)=O>C(N(CC)CC)C>[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][S:15][C:16]3[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=3[CH:18]=[O:19])[CH2:11][CH2:12]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 65578Oxalyl chlorideHCID 13768083HCID 13768083, compound

Product 1

HCID 13768078HCID 13768078, compoundYield 93.1%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

6.0 g of 2-[2-(4-phenylpiperazin-1-yl)ethylthio]benzylalcohol, 2.60 g of oxalyl chloride, 3.2 g of dimethylsulfoxide and 9.3 g of triethylamine are treated in the same manner as described above. 5.55 g of 2-[2-(4-phenylpiperazin-1-yl)ethylthio]benzaldehyde are obtained. Yield: 93%.

Sources & evidence

ORD record
ord-eb12f920bec740a89ef3f6602f83b842
Source dataset
uspto-grants-1987_08
Patent number
US04689327

Reaction notes

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