反应详情

To 2-chloro-5-(5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl)-benzoic acid methyl ester (48.0 mg, 0.2 mmol) in DMF (3 mL) was added 1-aminomethyl-cycloheptanol HCl (54.0 mg, 0.3 mmol), polymer-supported CDI (660 mg, 0.6 mmol), polymer-supported DMAP (280 mg, 0.20 mmol), and HOBt (40.0 mg, 0.3 mmol). The resulting reaction was shaken for 3 hours at ambient temperature. The reaction was filtered, washed with methanol, and the filtrate concentrated in vacuo. The residue was purified by reverse phase HPLC using a (5–100% gradient of 0.1% formic acid in acetonitrile and 0.1% formic acid in water) to yield 20 mg of the above named compound.

1. customThe resulting reaction
2. filtrationThe reaction was filtered
3. washwashed with methanol
4. concentrationthe filtrate concentrated in vacuo
5. customThe residue was purified by reverse phase HPLC
6. customto yield 20 mg of the