Hydrochloric Acid → HCID 131725846, compound

HRID 1791069Notes

Reaction equation

HRID 1791069 reaction equation
CC1C=CC([O:8][S:9]([C:12]2[CH:13]=[C:14]([NH:18][S:19]([C:22]3[CH:31]=[C:30]4[C:25]([CH:26]=[CH:27][C:28]([NH:32][C:33]([NH:35][C:36]5[CH:45]=[C:44]6[C:39]([CH:40]=[CH:41][C:42]([S:46]([NH:49][C:50]7[CH:51]=[C:52]([S:56]([O:59]C8C=CC(C)=CC=8)(=[O:58])=[O:57])[CH:53]=[CH:54][CH:55]=7)(=[O:48])=[O:47])=[CH:43]6)=[CH:38][CH:37]=5)=[O:34])=[CH:29]4)=[CH:24][CH:23]=3)(=[O:21])=[O:20])[CH:15]=[CH:16][CH:17]=2)(=[O:11])=[O:10])=CC=1.C[O-].[Na+:69].C1COCC1.Cl>CO.O>[Na+:69].[Na+:69].[S:56]([C:52]1[CH:51]=[C:50]([NH:49][S:46]([C:42]2[CH:43]=[C:44]3[C:39]([CH:38]=[CH:37][C:36]([NH:35][C:33]([NH:32][C:28]4[CH:29]=[C:30]5[C:25]([CH:24]=[CH:23][C:22]([S:19]([NH:18][C:14]6[CH:13]=[C:12]([S:9]([O-:11])(=[O:8])=[O:10])[CH:17]=[CH:16][CH:15]=6)(=[O:21])=[O:20])=[CH:31]5)=[CH:26][CH:27]=4)=[O:34])=[CH:45]3)=[CH:40][CH:41]=2)(=[O:48])=[O:47])[CH:55]=[CH:54][CH:53]=1)([OH:59])(=[O:57])=[O:58].[S:56]([C:52]1[CH:51]=[C:50]([NH:49][S:46]([C:42]2[CH:43]=[C:44]3[C:39]([CH:38]=[CH:37][C:36]([NH:35][C:33]([NH:32][C:28]4[CH:29]=[C:30]5[C:25]([CH:24]=[CH:23][C:22]([S:19]([NH:18][C:14]6[CH:13]=[C:12]([S:9]([O-:11])(=[O:8])=[O:10])[CH:17]=[CH:16][CH:15]=6)(=[O:21])=[O:20])=[CH:31]5)=[CH:26][CH:27]=4)=[O:34])=[CH:45]3)=[CH:40][CH:41]=2)(=[O:48])=[O:47])[CH:55]=[CH:54][CH:53]=1)([OH:59])(=[O:57])=[O:58]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 9832945HCID 9832945, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 131725846HCID 131725846, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To 20 mg (0.02 mole) of compound 112 was added 1.5 mL of 1.37 M sodium methoxide in methanol, 1 mL of water, and 0.5 mL of THF. The resulting solution was allowed to stir at ambient temperature for 2 days. The reaction was acidified with 1 N HCl (aqueous) and the organic volatiles removed in vacuo. The solid precipitate was collected by vacuum filtration to afford 15 mg of compound 114.

Workup

  1. customthe organic volatiles removed in vacuo
  2. filtrationThe solid precipitate was collected by vacuum filtration

Sources & evidence

ORD record
ord-86d1c4f394a0491a9858d47adc5f5943
Source dataset
uspto-grants-2006_07
Patent number
US07071231B2

Reaction notes

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