反应详情

温度

10 °C

A mixture of 2,3-dihydro-1H-indole (50 g), triethylamine (132 g) and tetrahydrofuran (1000 mL) was cooled down to 10° C. followed by the addition (over a period of 60 min) of a solution of 3-chloropropanoyl chloride (55 g) in tetrahydrofuran (400 mL). The mixture was filtered, and the remaining solution was evaporated in vacuo to dryness. The residue was purified by flash chromatography (eluent:ethyl acetate/heptane 1:3) giving the title compound as a crystalline white material (31 g).

1. filtrationThe mixture was filtered
2. customthe remaining solution was evaporated in vacuo to dryness
3. customThe residue was purified by flash chromatography (eluent:ethyl acetate/heptane 1:3)