反应详情

2,2-Dimethylpropionic acid [3-(2,2-dimethylpropionyloxymethyl)-2,6-dioxo-2,3,6,7-tetrahydropurin-1-yl]methyl ester (2.31 g) was dissolved in N,N-dimethylformamide (18 ml), and N-chlorosuccinimide (973 mg) was added to the solution while cooling on ice. Then, the mixture was stirred for 10 minutes on ice, and then at room temperature for 20 hours. The obtained reaction mixture was diluted with ethyl acetate, washed with water, and dried over anhydrous magnesium sulfate. After removing the solvent by distillation from the organic layer, the residue was purified by silica gel column chromatography to give 1.61 g of the title compound from the elution fraction of hexane-ethyl acetate (1:1).

1. temperaturewhile cooling on ice
2. waitat room temperature for 20 hours
3. customThe obtained reaction mixture
4. washwashed with water
5. dry with materialdried over anhydrous magnesium sulfate
6. customAfter removing the solvent
7. distillationby distillation from the organic layer
8. customthe residue was purified by silica gel column chromatography