Diiodomethane → HCID 22031592, compound

HRID 1792471Notes

Reaction equation

HRID 1792471 reaction equation
N[C:2]1[CH:15]=[CH:14][C:5]2[N:6]=[C:7]([CH2:9][CH2:10][CH2:11][C:12]#[N:13])[S:8][C:4]=2[CH:3]=1.N(OCCC(C)C)=O.[I:24]CI>O1CCCC1.[Cu]I>[I:24][C:2]1[CH:15]=[CH:14][C:5]2[N:6]=[C:7]([CH2:9][CH2:10][CH2:11][C:12]#[N:13])[S:8][C:4]=2[CH:3]=1

Participants

6

Reactant 3

HCID 6346DiiodomethaneHCID 8053Isoamyl NitriteHCID 22032522HCID 22032522, compound

Product 1

HCID 22031592HCID 22031592, compound

Reagents, catalysts & solvents 2

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 8028TetrahydrofuranSolvent

Procedure

1.1 g of 4-(6-amino-1,3-benzothiazol-2-yl)butane nitrile synthesized according to a method described in JP-A 5–194440, 2 mL isoamyl nitrite, 0.96 g of copper (I) iodide and 2 mL diiodomethane were heated in tetrahydrofuran at 80° C. for 1 hour. After the solvent was removed, the residue was purified by NH silica gel column to give 888 mg of the title compound as colorless crystals.

Workup

  1. customAfter the solvent was removed
  2. customthe residue was purified by NH silica gel column

Sources & evidence

ORD record
ord-7f4bc2a336c049ec819b1747c7048809
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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