Hydrochloric Acid → HCID 178478558, compound

HRID 1792601Notes

Reaction equation

HRID 1792601 reaction equation
[NH:1]1[C:5]([C:6]2[S:10][C:9]([C:11]3[C:15]([C:16]4[CH:17]=[CH:18][C:19]5[N:20]([C:22]([C:25]6[S:26][CH:27]=[CH:28][N:29]=6)=[CH:23][N:24]=5)[CH:21]=4)=[CH:14][N:13](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:12]=3)=[CH:8][CH:7]=2)=[N:4][N:3]=[N:2]1.[ClH:49].O>O1CCCC1.CO>[ClH:49].[ClH:49].[NH:1]1[C:5]([C:6]2[S:10][C:9]([C:11]3[C:15]([C:16]4[CH:17]=[CH:18][C:19]5[N:20]([C:22]([C:25]6[S:26][CH:27]=[CH:28][N:29]=6)=[CH:23][N:24]=5)[CH:21]=4)=[CH:14][NH:13][N:12]=3)=[CH:8][CH:7]=2)=[N:4][N:3]=[N:2]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 178420199HCID 178420199, compound

Product 1

HCID 178478558HCID 178478558, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

60 mg 6-{3-[5-(1H-tetrazol-5-yl)-thiophen-2-yl]-1-trityl-1H-pyrazol-4-yl}-3-thiazol-2-yl-imidazo[1,2-a]-pyridine obtained in Example 441 was dissolved in 8.0 mL solvent mixture of tetrahydrofuran and methanol (1:1), then 3.0 mL of 5 N hydrochloric acid was added thereto, and the mixture was left at room temperature for 3 hours. Water was poured into the reaction solution, and the precipitated crystals were collected by filtration and washed with diethyl ether, to give 14.5 mg of the title compound as pale pink crystals.

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with diethyl ether

Sources & evidence

ORD record
ord-433fc62a47ac470790c136dd6d824005
Source dataset
uspto-grants-2006_07
Patent number
US07074801B1

Reaction notes

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