Water → 3-(3-Bromopropoxy-4-methoxyphenyl)phenylmethanone

HRID 1792650Notes

Reaction equation

HRID 1792650 reaction equation
O[C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[O:16][CH3:17])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9]C=1)=O.[H-].[Na+].[Br:20][CH2:21][CH2:22][CH2:23]Br.[OH2:25].CN(C)[CH:28]=[O:29]>>[Br:20][CH2:21][CH2:22][CH2:23][O:25][C:3]1[CH:2]=[C:15]([O:16][CH3:17])[CH:14]=[CH:13][C:4]=1[C:5]1[CH:7]=[C:12]([CH:28]=[O:29])[CH:11]=[CH:10][CH:9]=1

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 80011,3-DibromopropaneHCID 24758Sodium hydrideHCID 41488933-Hydroxy-4-methoxybenzophenone

Product 1

HCID 219600893-(3-Bromopropoxy-4-methoxyphenyl)phenylmethanone

Conditions

Temperature
90 °C

Procedure

A solution of 3-hydroxy-4-methoxybenzophenone (4.6 g, 20 mmoles) in dimethylformamide (35ml) was treated with sodium hydride (600 mg, 25 mmoles) at 0° C. for 20 minutes, then 1,3-dibromopropane (5g, 24.7 moles was added in one portion. The mixture was heated at 90° C. for 1hr, and then stirred at room temperature for 2hr. At the end of the reaction, the mixture was poured into water (500 ml) and extracted with ethyl acetate (400 ml). The ethyl acetate solution was washed with water, brine and dried over anhydrous MgSO4. The solvent was removed and the crude oil was purified by flash chromatography over a silica gel column (SiO2, 85 g; eluted with 3l hexane:dichloromethane, 1.6; 3:7 hexane:dichloromethane, 1.41). The pure product thus obtained weighed 4.67 g, (66%) as an oil. Recrystallization twice from isopropyl ether (500 ml) gave analytically pure 3-(3-bromopropoxy-4methoxyphenyl)-phenylmethanone (2.42 g). m.p.=81°-83° C.

Workup

  1. customAt the end of the reaction
  2. extractionextracted with ethyl acetate (400 ml)
  3. washThe ethyl acetate solution was washed with water, brine
  4. dry with materialdried over anhydrous MgSO4
  5. customThe solvent was removed
  6. customthe crude oil was purified by flash chromatography over a silica gel column (SiO2, 85 g; eluted with 3l hexane:dichloromethane, 1.6; 3:7 hexane:dichloromethane, 1.41)
  7. customThe pure product thus obtained
  8. customRecrystallization twice from isopropyl ether (500 ml)

Sources & evidence

ORD record
ord-ad8fbdfe7468433bb767c80c12617838
Source dataset
uspto-grants-2006_07
Patent number
USRE039198E1

Reaction notes

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