反应详情

To a premixed solution of 2-methylbenzoic acid (7.5 mmol), EDCl (1.5 mmol) and DMAP (3.0 mmol) in DMA 40 mL and DCM 13 mL is added dimethylhydroxylamine hydrochloride (1.5 mmol). The reaction is stirred at room temperate over night. The reaction mixture is then filtered. The filtrate is diluted with EtOAc and washed with water, 10% NaHSO4 and brine. The solution is dried over Na2SO4 and the solvent is evaporated. A light yellow oil N-methoxy-N,2-dimethylbenzamide is obtained in 80% yield.

1. filtrationThe reaction mixture is then filtered
2. additionThe filtrate is diluted with EtOAc
3. washwashed with water, 10% NaHSO4 and brine
4. dry with materialThe solution is dried over Na2SO4
5. customthe solvent is evaporated