HCID 10075512, compound → HCID 10320163, compound

HRID 1795462Notes

Reaction equation

HRID 1795462 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[C:15]1[N:16]([CH3:38])[C:17](=[O:37])[C:18]([C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=2)=[C:19]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=2)[CH:20]=1)(C)(C)C>Cl.CCOC(C)=O>[NH2:7][CH2:8][CH2:9][N:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[C:15]1[N:16]([CH3:38])[C:17](=[O:37])[C:18]([C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=2)=[C:19]([C:21]2[CH:22]=[CH:23][N:24]=[CH:25][CH:26]=2)[CH:20]=1

Participants

4

Reactant 1

HCID 10075512HCID 10075512, compound

Product 1

HCID 10320163HCID 10320163, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

A suspension of {2-[2-(1-methyl-5-naphthalen-2-yl-6-oxo-1,6-dihydro-[4,4′]bipyridinyl-2-yl)-pyrrolidin-1-yl]-ethyl}-carbamic acid tert-butyl ester (100 mg, 0.19 mmol) in sat. HCl in EtOAc was stirred at RT for 4 h. Then the title compound was isolated by filtration and washed with dry EtOAc. MS (ES+): 425 (M+H)+.

Sources & evidence

ORD record
ord-39d9f8da757844b2991e6d639add8164
Source dataset
uspto-grants-2006_04
Patent number
US07026326B2

Reaction notes

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