Sodium Thiosulfate → HCID 68807616, compound

HRID 1796238Notes

Reaction equation

HRID 1796238 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13](=[O:30])[NH:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2SC)=[CH:17][C:16]=1[Cl:29])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:32]1C=C(C=CC=1)C(OO)=O.[O-:42][S:43]([O-:46])(=S)=O.[Na+].[Na+]>CCOC(C)=O>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13](=[O:30])[NH:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=2[S:43]([CH3:32])(=[O:46])=[O:42])=[CH:17][C:16]=1[Cl:29])=[O:7])([CH3:3])([CH3:2])[CH3:4]

Participants

5

Reactant 3

HCID 24477Sodium ThiosulfateHCID 70297m-Chloroperbenzoic acidHCID 68807013HCID 68807013, compound

Product 1

HCID 68807616HCID 68807616, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-(3-Chloro-2′-methylsulfanyl-biphenyl-4-ylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (1 g, 2 mmol) was dissolved in 20 mL EtOAc, added m-chloroperoxybenzoic acid (2.6 g, 8.9 mmol) in one portion and stirred at ambient temperature for 3 hours. A 10% aqueous solution (30 mL) of Na2S2O3 was added to the vigorously stirring reaction in order to quench peroxide. After 20 minutes the solution was diluted with 100 mL EtOAc, separated layers, washed organics with sat. NaHCO3 (3×100 mL), brine, dried with MgSO4, filtered and concentrated to yield title compound as a clear oil. (1 g, 100%) APCI (AP−): 477.1, 479.1 (M−H)−.

Workup

  1. stirringvigorously stirring
  2. customreaction in order
  3. customto quench peroxide
  4. additionAfter 20 minutes the solution was diluted with 100 mL EtOAc
  5. customseparated layers
  6. washwashed organics with sat. NaHCO3 (3×100 mL), brine
  7. dry with materialdried with MgSO4
  8. filtrationfiltered
  9. concentrationconcentrated

Sources & evidence

ORD record
ord-f5876556ca0e4b04a98a1e530872e96d
Source dataset
uspto-grants-2006_04
Patent number
US07030141B2

Reaction notes

Loading…