Tetrahydrofuran → 5-benzyl-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-4-vinyl-1H-benzoimidazole
Reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[c:9]([I:32])[c:10]2[c:11]([n:12]([CH2:24][CH2:25][O:26][CH3:27])[c:13](-[c:15]3[cH:16][cH:17][c:18]([CH:21]([CH3:22])[CH3:23])[cH:19][cH:20]3)[n:14]2)[c:28]([O:30][CH3:31])[cH:29]1.[CH2:33]([CH2:34][CH2:46][CH3:47])[Sn:35]([CH2:36][CH2:37][CH2:38][CH3:39])([CH2:40][CH2:41][CH2:42][CH3:43])[CH:44]=[CH2:45].[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[Pd:53]([Cl:54])[Cl:55].[c:56]1([P:57]([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[cH:70][cH:71][cH:72][cH:73][cH:74]1.[c:75]1([P:76]([c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)[c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[cH:89][cH:90][cH:91][cH:92][cH:93]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[c:8]1[c:9]([CH:33]=[CH2:34])[c:10]2[c:11]([n:12]([CH2:24][CH2:25][O:26][CH3:27])[c:13](-[c:15]3[cH:16][cH:17][c:18]([CH:21]([CH3:22])[CH3:23])[cH:19][cH:20]3)[n:14]2)[c:28]([O:30][CH3:31])[cH:29]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-af89e4a7bc59468ebfa5883f8c6d9dcc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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