反应详情

温度

8 °C

The compound (50 mg, 0.16 mmol) prepared in step (b) of Example 125 was dissolved in anhydrous DMF. Potassium carbonate (44 mg) and 66 mg of the compound prepared in step (a) of Example 93 were added to the solution. The mixture was stirred at 50° C. for 20 hr and further at 8° C. for 4.5 hr. The reaction solution was diluted with ethyl acetate, and the dilution was washed twice with water, followed by drying over anhydrous magnesium sulfate. The solvent was removed by distillation under the reduced pressure. The residue was purified by column chromatography (development system, methylene chloride:methanol=30:1) to give the title compound (46 mg, yield 71%) as a white foam.

1. washthe dilution was washed twice with water
2. dry with materialby drying over anhydrous magnesium sulfate
3. customThe solvent was removed by distillation under the reduced pressure
4. customThe residue was purified by column chromatography (development system, methylene chloride:methanol=30:1)