Hydrochloric Acid → 1-Amino-2-(4-methoxyphenyl)propan-2-ol

Into a 100 mL single-neck flask, 28.5 mL of trimethylsilyl cyanide was added dropwise to 10 g of 4′-methoxyacetophenone and 2.28 g of zinc iodide while stirring under a nitrogen atmosphere at room temperature. The reaction was allowed to stir at this temperature overnight. In the morning, the mixture was diluted with methylene chloride (100 mL) and the organic layer was backwashed once with sat. Na2HCO3, dried over MgSO4, and concentrated under reduced vacuum to yield 13 g. as a tan oil. Because of possible stability problems, this material was used immediately and placed into 200 mL THF in a 500 mL single-neck flask. While stirring at room temperature under a nitrogen atmosphere, 70 mL of BH3-THF complex was added syringe wise and the reaction was stirred overnight. In the morning, 10 mL of concentrated hydrochloric acid was added dropwise at room temperature and severe foaming was present. The mixture was then concentrated under reduced vacuum. The resulting HCl salt was liberated while being stirred in 1N NaOH and the free amine was extracted into ethyl acetate. This organic layer was washed with H2O, dried over Na2SO4, and concentrated under reduced vacuum to yield 7.31 g. of a 2 spot material. This material was purified via silica gel chromatography employing the Water's prep. 2000 and eluting with a solvent of methylene chloride/methanol 9:1 to yield intermediate title compound (3.01 g, 24%) as an oil as the top spot. (FD) M.S. 180.3 (M*−1).

1. stirringto stir at this temperature overnight
2. dry with materialdried over MgSO4
3. concentrationconcentrated under reduced vacuum
4. customto yield 13 g
5. stirringWhile stirring at room temperature under a nitrogen atmosphere
6. addition70 mL of BH3-THF complex was added syringe wise
7. stirringthe reaction was stirred overnight
8. concentrationThe mixture was then concentrated under reduced vacuum
9. stirringwhile being stirred in 1N NaOH
10. extractionthe free amine was extracted into ethyl acetate
11. washThis organic layer was washed with H2O
12. dry with materialdried over Na2SO4
13. concentrationconcentrated under reduced vacuum
14. customto yield 7.31 g
15. customThis material was purified via silica gel chromatography
16. wash2000 and eluting with a solvent of methylene chloride/methanol 9:1

ORD record

ord-cbaf02040dee4690b73412ae7f9395ea

Source dataset

uspto-grants-2006_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07034045B1