Hydrochloric Acid → HCID 22176280, compound

HRID 1797606Notes

Reaction equation

HRID 1797606 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[N:10]([CH2:31][CH:32]([CH3:34])[CH3:33])[C:11](=[O:30])[C:12]2[C:17]([C:18]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[CH:16][C:15]([C:25]1[N:26]=[N:27][NH:28][N:29]=1)=[CH:14][CH:13]=2)(C)(C)C.[ClH:36]>O1CCCC1.C(OCC)(=O)C>[ClH:36].[NH2:7][CH2:8][C:9]1[N:10]([CH2:31][CH:32]([CH3:34])[CH3:33])[C:11](=[O:30])[C:12]2[C:17]([C:18]=1[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[CH:16][C:15]([C:25]1[N:26]=[N:27][NH:28][N:29]=1)=[CH:14][CH:13]=2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22175663HCID 22175663, compound

Product 1

HCID 22176280HCID 22176280, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

Tert-butyl[2-isobutyl-1-oxo-4-phenyl-6-(2H-tetrazol-5-yl)-1,2-dihydro-3-isoquinolinyl]methylcarbamate (0.15 g, 0.32 mmol) was dissolved in tetrahydrofuran (4 mL) and a solution (4 mL) of 4N hydrogen chloride in ethyl acetate was added thereto. This mixture was stirred at room temperature for 17 h, and the precipitated crystals were collected by filtration to give the title compound (0.13 g, 97%) as colorless crystals.

Workup

  1. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-963d2acdca1d42ac893f7a230601a96b
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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