Hydrochloric Acid → HCID 22175706, compound

HRID 1797608Notes

Reaction equation

HRID 1797608 reaction equation
[NH2:1][CH2:2][C:3]1[N:4]([CH2:22][CH:23]([CH3:25])[CH3:24])[C:5](=[O:21])[C:6]2[C:11]([C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[CH:10][C:9]([S:19][CH3:20])=[CH:8][CH:7]=2.[ClH:26]>C(OCC)(=O)C>[ClH:26].[NH2:1][CH2:2][C:3]1[N:4]([CH2:22][CH:23]([CH3:25])[CH3:24])[C:5](=[O:21])[C:6]2[C:11]([C:12]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[CH:10][C:9]([S:19][CH3:20])=[CH:8][CH:7]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22175707HCID 22175707, compound

Product 1

HCID 22175706HCID 22175706, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

3-(Aminomethyl)-2-isobutyl-6-(methylsulfanyl)-4-phenyl-1(2H)-isoquinolinone (0.13 g, 0.37 mmol) was dissolved in ethyl acetate (3 mL) and a solution (1 mL) of 4N hydrogen chloride in ethyl acetate was added thereto. The mixture was stirred for 5 min and concentrated under reduced pressure. The obtained residue was crystallized from ethyl acetate-diisopropyl ether (1:2) to give the title compound (0.14 g, 95%) as colorless crystals.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe obtained residue was crystallized from ethyl acetate-diisopropyl ether (1:2)

Sources & evidence

ORD record
ord-9da31a1ec18f4394a1ce2dde600483ff
Source dataset
uspto-grants-2006_04
Patent number
US07034039B2

Reaction notes

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