Hydrochloric Acid → HCID 86609819, compound

HRID 1799755Notes

Reaction equation

HRID 1799755 reaction equation
C(N(CC)C(C)C)(C)C.Cl[C:11]([O:13][CH2:14][Cl:15])=[O:12].[CH2:16]([NH:20][CH:21]([CH3:23])[CH3:22])[CH:17]([CH3:19])[CH3:18].Cl>C1(C)C=CC=CC=1>[CH2:16]([N:20]([CH:21]([CH3:23])[CH3:22])[C:11](=[O:12])[O:13][CH2:14][Cl:15])[CH:17]([CH3:19])[CH3:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 62754Chloromethyl chloroformateHCID 81531DiisopropylethylamineHCID 123728902-Methyl-N-(propan-2-yl)propan-1-amine

Product 1

HCID 86609819HCID 86609819, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Toluene (9 ml), 1.42 ml of N,N-diisopropylethylamine, and 0.56 ml of chloromethyl chloroformate were added in that order to 870 mg of N-isobutylisopropylamine, and the mixture was stirred at room temperature for 16 hr. 1 N hydrochloric acid (15 ml) was added thereto, followed by separation. The organic layer was washed with 15 ml of a 5% aqueous sodium hydrogencarbonate solution and 15 ml of 20% brine, was dried over anhydrous magnesium sulfate, and was filtered. The solvent was removed by distillation under the reduced pressure to give 1.23 g of chloromethyl N-isobutyl-N-isopropylcarbamate.

Workup

  1. customfollowed by separation
  2. washThe organic layer was washed with 15 ml of a 5% aqueous sodium hydrogencarbonate solution and 15 ml of 20% brine
  3. dry with materialwas dried over anhydrous magnesium sulfate
  4. filtrationwas filtered
  5. customThe solvent was removed by distillation under the reduced pressure

Sources & evidence

ORD record
ord-99b2085f0d454d27ad60400dccab667d
Source dataset
uspto-grants-2013_01
Patent number
US08344154B2

Reaction notes

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