Potassium Carbonate → HCID 68419363, compound

HRID 1800438Notes

Reaction equation

HRID 1800438 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:21])[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].Cl[C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][N:24]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:8][C:7]1[CH:6]=[CH:5][C:4]([NH:9][C:10](=[O:21])[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:18])([F:19])[F:20])[CH:12]=2)=[CH:3][C:2]=1[O:1][C:23]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][N:24]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 783082-Chloro-5-nitropyridineHCID 64793275HCID 64793275, compound

Product 1

HCID 68419363HCID 68419363, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the same method as in Example C1(v), the title compound (8.35 g, 98%) was obtained as an orange oil using N-(3-hydroxy-4-methylphenyl)-3-(trifluoromethyl)benzamide (6.00 g, 20.3 mmol), 2-chloro-5-nitropyridine (3.22 g, 20.3 mmol), potassium carbonate (8.43 g, 60.9 mmol) and N,N-dimethylformamide (150 mL) as starting materials. The title compound was used for the next reaction without further purification operation.

Sources & evidence

ORD record
ord-f5973eafa9e14e5eb2586d05e23ddddb
Source dataset
uspto-grants-2013_01
Patent number
US08344135B2

Reaction notes

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