反应详情

N-{5-[(2-Amino[1,3]thiazolo[5,4-b]pyridin-5-yl)oxy]-2-chlorophenyl}-2,2,2-trifluoroacetamide (5.0 g, 12.86 mmol) produced in Example C114(iv) was dissolved in pyridine (25 mL), cyclopropanecarbonyl chloride (1.284 mL, 14.15 mmol) was added dropwise under ice-cooling, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was treated with aqueous sodium hydrogen carbonate solution (100 mL), and diluted with ethyl acetate (100 mL), and the organic layer was collected. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residual solid was crystallized from ethyl acetate (30 mL), collected by filtration, and dried to give the title compound (3.46 g, 59%) as a white solid.

1. temperaturecooling
2. customthe organic layer was collected
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe residual solid was crystallized from ethyl acetate (30 mL)
6. filtrationcollected by filtration
7. customdried