Hydrochloric Acid → chroman-3-one

Example 1B (3.472 g, 19.7 mmol) was dissolved in dichloromethane (45 mL) to which was added triethylamine (3.5 mL) and diphenylphosphoryl azide (5.97 g, 21.7 mmol) in toluene (20 mL). The flask was equipped with a Dean-Stark trap and the mixture was heated to reflux. Toluene (45 mL) was added after one hour and the mixture was reflux for an 2 additional hours after which it was cooled to ambient temperature. 6N hydrochloric acid (50 mL) and toluene (20 mL) were added and the biphasic mixture refluxed for 3.5 hours followed by cooling to ambient temperature. Ethyl acetate (100 mL) and water (100 mL) were added, and the separated organic layer was washed sequentially with saturated sodium bicarbonate (2×100 mL), brine, dried over anhydrous sodium sulfate and filtered. The solution was concentrated under reduced pressure and chromatographed on silica gel eluting with 0-to-40% ethyl acetate in hexane to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 3.68 (s, 2H), 4.46 (s, 2H), 7.04 (m, 2H), 7.23 (m, 2H). MS (DCI) m/z 148.04 (M+NH4—H2O)+.

1. customThe flask was equipped with a Dean-Stark trap
2. temperaturethe mixture was heated to reflux
3. temperaturethe mixture was reflux for an 2 additional hours after which it
4. temperaturethe biphasic mixture refluxed for 3.5 hours
5. temperatureby cooling to ambient temperature
6. washthe separated organic layer was washed sequentially with saturated sodium bicarbonate (2×100 mL), brine
7. dry with materialdried over anhydrous sodium sulfate
8. filtrationfiltered
9. concentrationThe solution was concentrated under reduced pressure
10. customchromatographed on silica gel eluting with 0-to-40% ethyl acetate in hexane

ORD record

ord-ecda043b25f14ff9927f8d49b6cce8dd

Source dataset

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08350083B2