huagongshe.com
HRID1807476

反应详情

EQUATION

反应方程式

HRID 1807476 的结构方程式

REACTANTS

反应物

3
结构：O=C=NCc1ccccc1
HCID76639

Benzyl isocyanate

C8H7NO

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：Nc1ccc2cnccc2c1
HCID588991

6-Aminoisoquinoline

C9H8N2

PRODUCTS

生成物

1
结构：O=C(NCc1ccccc1)Nc1ccc2cnccc2c1
HCID44276961

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To 6-aminoisoquinoline in DMF is added DMAP and benzyl isocyanate and the solution was stirred at room temperature for 4 hours. The mixture was poured into NaHCO3 (sat), extracted with EtOAc, dried (Na2SO4), filtered and evaporated. Flash chromatography (SiO2, 5% MeOH/CH2Cl2) provided 1-benzyl-3-(isoquinolin-6-yl)urea (E88).

WORKUP

后处理

  1. extractionextracted with EtOAc
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. customevaporated