Triethylamine → N-(2,4-dimethoxybenzyl)-1,2,4-thiadiazol-5-amine

2,4 Dimethoxybenzaldehyde (4.1 g, 24 mmol, 1 eq), 2 amino-1,2,4-thiadiazole (2.5 g, 24.7 mmol, 1 eq), Et3N (3.04 g, 30 mmol, 1 eq) and piperidine (25 mg, 0.297 mmol, 0.012 eq) were combined in DCM (100 ml) and the reaction mixture heated to reflux over sieves for 72 hours. The reaction mixture was cooled to room temperature and chlorotitaniumisopropoxide (1M solution in hexane, 29.7 ml, 29.7 mmol, 1.2 eq) was added and the reaction mixture stirred at room temperature for 15 minutes. The sieves were removed by filtration and the reaction mixture diluted with MeOH (50 ml). Sodium borohydride (3.7 g, 99 mmol, 4.0 eq) was added portionwise and the reaction mixture stirred for 1 hour. The reaction mixture was diluted with saturated sodium hydrogen carbonate (100 ml) and the resulting titanium precipitate removed by filtration through Celite. The filtrate was dried over sodium sulphate, filtered and evaporated in vacuo. The crude material was purified by column chromatography eluting with 15-60% ethyl acetate: heptane to yield the title compound (111 g, 4.38 mmol, 17%).

1. temperaturethe reaction mixture heated
2. temperatureto reflux over sieves for 72 hours
3. customThe sieves were removed by filtration
4. additionthe reaction mixture diluted with MeOH (50 ml)
5. stirringthe reaction mixture stirred for 1 hour
6. customthe resulting titanium precipitate removed by filtration through Celite
7. dry with materialThe filtrate was dried over sodium sulphate
8. filtrationfiltered
9. customevaporated in vacuo
10. customThe crude material was purified by column chromatography
11. washeluting with 15-60% ethyl acetate

ORD record

ord-4140acea94b847e2beb0af022f4ef652

Source dataset

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08357711B2