Hydrochloric Acid → 5,6-dimethyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane hydrochloride

HRID 1808915Notes

Reaction equation

HRID 1808915 reaction equation
[ClH:1].[CH3:2][CH:3]1[CH:9]([CH3:10])[N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6][N:5]([C:18](=[O:31])[C:19]2[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:20]=2[N:26]2[N:30]=[CH:29][CH:28]=[N:27]2)[CH2:4]1>C(OCC)(=O)C>[ClH:1].[CH3:10][CH:9]1[CH:3]([CH3:2])[CH2:4][N:5]([C:18](=[O:31])[C:19]2[CH:24]=[C:23]([CH3:25])[CH:22]=[CH:21][C:20]=2[N:26]2[N:30]=[CH:29][CH:28]=[N:27]2)[CH2:6][CH2:7][NH:8]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59527669tert-butyl 6,7-dimethyl-4-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane-1-carboxylate

Product 1

HCID 685121195,6-dimethyl-1-[5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride gas was bubbled through a 0° C. solution of the compound 1-6 (385 mg, 0.93 mmol) in ethyl acetate (5 mL) for 1 minute. The reaction was sealed and stirred for 40 minutes. Concentration in vacuo gave the titled compound as a white solid. Data for 1-7: LC/MS: m/z (M+Na)=314.2 found; 314.4 calculated.

Workup

  1. customThe reaction was sealed
  2. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-db9b835e3e0640aeb8281618292c64bd
Source dataset
uspto-grants-2013_01
Patent number
US08362009B2

Reaction notes

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