反应详情

温度

100 °C

A mixture of 8-Methanesulfonyl-3-(4-methoxy-phenyl)-imidazo[1,2-a]pyrazine (0.150 g, 0.495 mmol), 3-Aminomethyl-benzenesulfonamide TFA salt (0.223 g, 0.742 mmol), DIPEA (0.260 mL, 1.50 mmol) in NMP (0.66 mL) is stirred at 100° C. for 16 hours. The reaction mixture is diluted with AcOEt, washed with water and brine, dried with MgSO4 anh., filtered and evaporated. The crude is purified by column chromatography using a gradient of (Pet.Ether 40-60/AcOEt: 1/1 to 0/1) to give 3-{[3-(4-Methoxy-phenyl)-imidazo[1,2-a]pyrazin-8-ylamino]-methyl}-benzenesulfonamide as a pale yellow solid (0.135 g, 67%). LC-MS m/z 410 [M+H]+.

1. washwashed with water and brine
2. dry with materialdried with MgSO4 anh.
3. filtrationfiltered
4. customevaporated
5. customThe crude is purified by column chromatography