反应详情

温度

100 °C

To a solution of 3-hydroxypyridine (3.25 g) in dimethylformamide (75 ml), 6.75 g of potassium carbonate and 5.0 g of 1,3-difluoro-5-nitrobenzene were added, and the reaction solution was stirred at 100° C. for 6 hours. The reaction solution was cooled, thereafter diluted with a saturated aqueous ammonium chloride solution, and extracted with ethyl acetate. The combined organic layers were washed with water and a saturated saline solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resultant residue was purified by silica gel chromatography to yield the title compound as a yellow oil.

1. temperatureThe reaction solution was cooled
2. extractionextracted with ethyl acetate
3. washThe combined organic layers were washed with water
4. dry with materiala saturated saline solution and dried over anhydrous sodium sulfate
5. distillationThe solvent was distilled off under reduced pressure
6. customthe resultant residue was purified by silica gel chromatography