Iodoethane → Ethyl 4-ethoxy-3-hydroxybenzoate

HRID 1810838Notes

Reaction equation

HRID 1810838 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([OH:12])[CH:6]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+].I[CH2:21][CH3:22]>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:21][CH3:22])=[C:7]([OH:12])[CH:6]=1)[CH3:2]

Participants

5

Reactant 3

HCID 6340Iodoethane2×HCID 11430Potassium Carbonate2×HCID 77547Ethyl 3,4-Dihydroxybenzoate

Product 1

HCID 11106619Ethyl 4-ethoxy-3-hydroxybenzoate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3,4-Dihydroxybenzoic acid ethyl ester (3.00 g, 16.0 mmol) was suspended in DMF (10 ml), potassium carbonate (2.21 g, 16.0 mmol) was added, the mixture was stirred for 5 min at room temperature, and then iodoethane (2.49 g, 16.0 mmol) was added. The mixture was stirred overnight, the addition of potassium carbonate and of iodoethane was repeated, and the mixture was stirred overnight again. The mixture was partitioned between 2 N hydrochloric acid and EA, the aqueous phase extracted with EA, and the combined organic extracts were washed with a saturated sodium hydrogencarbonate solution and a saturated sodium chloride solution, dried over sodium sulfate, filtered, and evaporated to dryness. The residue was purified by silica gel chromatography (HEP/EA gradient).

Workup

  1. stirringThe mixture was stirred overnight
  2. stirringthe mixture was stirred overnight again
  3. customThe mixture was partitioned between 2 N hydrochloric acid and EA
  4. extractionthe aqueous phase extracted with EA
  5. washthe combined organic extracts were washed with a saturated sodium hydrogencarbonate solution
  6. dry with materiala saturated sodium chloride solution, dried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated to dryness
  9. customThe residue was purified by silica gel chromatography (HEP/EA gradient)

Sources & evidence

ORD record
ord-6e3adcc9ab18415d867194f9701cb766
Source dataset
uspto-grants-2013_01
Patent number
US08362073B2

Reaction notes

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