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HRID1812462

反应详情

EQUATION

反应方程式

HRID 1812462 的结构方程式

REACTANTS

反应物

3
结构：O=C(CBr)c1ccccc1
HCID6259

2-Bromoacetophenone

C8H7BrO

结构：Cc1cccc(C)n1
HCID7937

2,6-Dimethylpyridine

C7H9N

结构：C#CCCCCC=O
HCID11355455

6-Heptynal

C7H10O

PRODUCTS

生成物

2
结构：C#CCCC[C@@H](C=O)CC(=O)c1ccccc1
HCID178444626

未命名化合物

结构：C#CCCC[C@H](C=O)CC(=O)c1ccccc1
HCID178444627

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

3
结构：C[Si](C)(C)OC(c1ccccc1)(c1ccccc1)[C@@H]1CCCN1
催化剂HCID11198150

(2S)-2-{Diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine

C20H27NOSi

结构：F[P-](F)(F)(F)(F)F.[Ir+3].[c-]1ccccc1-c1ccccn1.[c-]1ccccc1-c1ccccn1.c1ccc(-c2ccccn2)nc1
催化剂HCID54589530

未命名化合物

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

5 次

CONDITIONS

反应条件

温度
22 °C

WORKUP

后处理

  1. aliquot4 uL mixture of each reacted solution was collected and diluted with 36 uL ACN
  2. addition4 uL mixture of each reacted solution was collected and diluted with 36 uL ACN
  3. additionchiral resolving regent (150 mM in DCM, 40 uL)
  4. additionCuI with DIPEA (400 mM in ACN) 40 uL
  5. additioninternal standard 1-phenylprop-2-yn-1-ol (4) (25 mM in ACN) 40 uL
  6. stirring未记录说明
  7. aliquotAfter the reaction, 10 uL of supernatant for each reaction was transferred to another 96-well plate
  8. additionAfter the reaction, 10 uL of supernatant for each reaction was transferred to another 96-well plate and diluted with 190 uL ACN before the IM-MS analysis