Chloride → HCID 11401639, compound

HRID 1814816Notes

Reaction equation

[NH2:1][CH:2]([C:4]([OH:6])=[O:5])[CH3:3].C(N(CC)CC)C.[Cl-].[C:15](Cl)(=[O:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>>[C:15]([NH:1][CH:2]([CH3:3])[C:4]([OH:6])=[O:5])(=[O:23])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

Reactant 4

HCID 312Chloride

HCID 602DL-alanine

HCID 8124Octanoyl chloride

HCID 8471Triethylamine

Product 1

HCID 11401639HCID 11401639, compound

Procedure

The preparation is carried out analogously to the procedure of example 1A using 16.5 g (0.185 mol) of D,L-alanine, 41.23 g (0.407 mol) of triethylamine, 44.27 g (0.407 mol) of trimethylsilyl)l chloride and 30.12 g (0.185 mol) of octanoyl chloride. The product crystallizes from toluene/n-hexane.

Workup

customThe product crystallizes from toluene/n-hexane

Sources & evidence

ORD record: ord-0a1f75fda78c4b0da530f08bb9fe7766
Source dataset: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06878708B2

Reaction notes

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