Hydrochloric Acid → HCID 69744790, compound

HRID 1815841Notes

Reaction equation

HRID 1815841 reaction equation
[CH3:1][C@H:2]1[C@@H:7]([C:8]2[C:16]3[O:15][CH:14]=[CH:13][C:12]=3[CH:11]=[C:10]([F:17])[CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3]1.[ClH:18]>C(OCC)(=O)C.C(OCC)C>[ClH:18].[CH3:1][C@H:2]1[C@@H:7]([C:8]2[C:16]3[O:15][CH:14]=[CH:13][C:12]=3[CH:11]=[C:10]([F:17])[CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59012639HCID 59012639, compound

Product 1

HCID 69744790HCID 69744790, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 0.48 gm (2.1 mMol) cis-3-methyl-4-(5-fluorobenzofur-7-yl)piperidine in 5 mL ethyl acetate was treated with 5.0 mL 1N hydrogen chloride in diethyl ether. The resulting slurry was stirred for 1.5 hours at 0° C. and was then filtered under reduced pressure. The solid was washed with diethyl ether and dried under reduced pressure to provide 0.50 gm (89%) of the title compound.

Workup

  1. filtrationwas then filtered under reduced pressure
  2. washThe solid was washed with diethyl ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-1ebef3c2ca56460089897e4030eb7bbf
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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