反应详情

2-Methoxy-5-nitroaniline (0.4 g, 2.38 mmol) was dissolved into CH2Cl2 (12 ml). To this solution was added EDC (1.37 g, 7.14 mmol), HOBT (964 mg, 7.14 mmol), DIEA (2.07 ml, 11.9 mmol) and acrylic acid (0.65 ml, 9.51 mmol). The reaction mixture was kept at RT for 4 h. The reaction mixture was diluted with EtOAc, washed with water, 1 N HCl, dilute NaHCO3, then brine. The organic layer was dried over Na2SO4, filtered, and evaporated in vacuo. The residue was purified by column chromatography using 2:1 EtOAc/hexanes as the solvent to give N-(2-methoxy-5-nitrophenyl)-acrylamide.

1. washwashed with water, 1 N HCl, dilute NaHCO3
2. dry with materialThe organic layer was dried over Na2SO4
3. filtrationfiltered
4. customevaporated in vacuo
5. customThe residue was purified by column chromatography