反应详情

To a mixture of the product from Step H (0.40 g, 1.1 mmol) in THF (60 mL) was added 1 N HCl (26 mL). After stirring for 40 min a saturated solution of sodium bicarbonate (150 mL) was added and the mixture was extracted with EtOAc (3×100 mL). The combined extracts were dried and evaporated to a residue, which was purified by chromatography (silica, 50% EtOAc/hexane) to give an oil (0.29 g, 92%): LC/MS (+APCI) m/z 374 (M+H).

1. additionwas added
2. extractionthe mixture was extracted with EtOAc (3×100 mL)
3. customThe combined extracts were dried
4. customevaporated to a residue, which
5. customwas purified by chromatography (silica, 50% EtOAc/hexane)