Potassium Carbonate → HCID 22497241, compound

Temperature

60 °C

A mixture of 1-(6-chloro-1H-indol-3-yl)-2,2,2-trifluoro-ethanone (300 mg, 1.21 mmol), potassium carbonate (419 mg, 3.03 mmol), and (bromomethyl)-cyclopropane (0.18 mL, 1.82 mmol) in N,N-dimethylformamide (4 mL) in a sealed reaction vessel was stirred at 60° C. for 16 h. At this time, the reaction was cooled to 25° C. and partitioned between water (30 mL) and ethyl acetate (30 mL). This mixture was treated with a 1N aqueous hydrochloric acid solution (5 mL), shaken, and separated. The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo to afford a yellow oil. The resulting oil was treated with a 20% aqueous sodium hydroxide solution (7 mL) and was heated at 110° C. for 2 d. At this time, the reaction was cooled to 25° C. and was partitioned between water (75 mL) and ethyl acetate (75 mL). This solution was treated with a 1N aqueous hydrochloric acid solution (30 mL), shaken, and separated. The organic layer was washed with a saturated aqueous sodium chloride solution (1×50 mL), dried over magnesium sulfate, filtered, and concentrated in vacuo to afford 6-chloro-1-cyclopropylmethyl-1H-indole-3-carboxylic acid (287 mg, 95%) as a pale yellow solid: mp 219-220° C.; EI-HRMS m/e calcd for C13H12ClNO2 (M+) 249.0556, found 249.0558.

1. customin a sealed reaction vessel
2. temperatureAt this time, the reaction was cooled to 25° C.
3. custompartitioned between water (30 mL) and ethyl acetate (30 mL)
4. additionThis mixture was treated with a 1N aqueous hydrochloric acid solution (5 mL)
5. stirringshaken
6. customseparated
7. dry with materialThe organic layer was dried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customto afford a yellow oil
11. temperaturewas heated at 110° C. for 2 d
12. temperatureAt this time, the reaction was cooled to 25° C.
13. customwas partitioned between water (75 mL) and ethyl acetate (75 mL)
14. additionThis solution was treated with a 1N aqueous hydrochloric acid solution (30 mL)
15. stirringshaken
16. customseparated
17. washThe organic layer was washed with a saturated aqueous sodium chloride solution (1×50 mL)
18. dry with materialdried over magnesium sulfate
19. filtrationfiltered
20. concentrationconcentrated in vacuo

ORD record

ord-1c3e18ce513e4fcba2a69b94e1dd88b6

Source dataset

uspto-grants-2005_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06881844B2