反应详情

To a solution of trans-4-methylcyclohexanol (4.55 g) in ethyl acetate (50 ml) were added successively triethylamine (7.22 ml) and methanesulfonyl chloride (3.38 ml) with stirring under ice-water bath. The mixture was stirred at the same temperature for 1 hour. To the reaction mixture were added ethyl acetate (50 ml), water (50 ml) and 1N hydrochloric acid (20 ml) with stirring. The organic layer was separated, washed successively with water, saturated aqueous sodium hydrogen carbonate, water and saturated aqueous sodium chloride, dried over magnesium sulfate and evaporated in vacuo to give trans-4-methylcyclohexyl methanesulfonate (8.36 g).

1. stirringThe mixture was stirred at the same temperature for 1 hour
2. stirringwith stirring
3. customThe organic layer was separated
4. washwashed successively with water, saturated aqueous sodium hydrogen carbonate, water and saturated aqueous sodium chloride
5. dry with materialdried over magnesium sulfate
6. customevaporated in vacuo