反应详情

温度

70 °C

0.80 g of 2-hydroxy-4-(trifluoromethyl)benzaldehyde was dissolved in 8 ml dimethylformamide, and 0.78 g of ethyl iodide and 0.69 g of potassium carbonate were added, and the mixture was stirred at 70° C. for 2 hours. The reaction solution was diluted with water and then extracted with ethyl acetate. The organic layer was successively washed with 1N hydrochloric acid and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated. The residue was subjected to silica gel column chromatography, and from fractions eluted with hexane-ethyl acetate (5:1), 0.60 g of 2-ethoxy-4-(trifluoromethyl)benzaldehyde was obtained.

1. extractionextracted with ethyl acetate
2. washThe organic layer was successively washed with 1N hydrochloric acid and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customthe solvent was evaporated
5. washfrom fractions eluted with hexane-ethyl acetate (5:1)