Hydrochloric Acid → HCID 68871190, compound

HRID 1817853Notes

Reaction equation

HRID 1817853 reaction equation
NC1C=C(S(C)(=O)=O)C=CC=1NCC1CC1.[CH:17]1([CH2:20][N:21]2[C:25]3[CH:26]=[CH:27][C:28]([S:30]([CH3:33])(=[O:32])=[O:31])=[CH:29][C:24]=3[N:23]=[C:22]2[CH2:34][C:35]([CH3:38])([CH3:37])[CH3:36])[CH2:19][CH2:18]1.[ClH:39]>C(OCC)(=O)C>[ClH:39].[CH:17]1([CH2:20][N:21]2[C:25]3[CH:26]=[CH:27][C:28]([S:30]([CH3:33])(=[O:31])=[O:32])=[CH:29][C:24]=3[N:23]=[C:22]2[CH2:34][C:35]([CH3:38])([CH3:37])[CH3:36])[CH2:18][CH2:19]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11587800HCID 11587800, compoundHCID 43447972HCID 43447972, compound

Product 1

HCID 68871190HCID 68871190, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

The title compound was prepared according to the procedure described in Step F of Example 1 using 2-amino-1-(N-cyclopropylmethylamino)-4-(methylsulfonyl)benzene instead of 2-amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzene. Obtained 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-5-(methylsulfonyl)-1H-benzimidazole was dissolved in ethyl acetate and to the solution was added 4 N hydrogen chloride in ethyl acetate. Precipitate was collected by filtration to afford the title compound as a white solid.

Workup

  1. customThe title compound was prepared
  2. filtrationPrecipitate was collected by filtration

Sources & evidence

ORD record
ord-f1f36ffe21864173921abf8529eefeaf
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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