反应详情

温度

0 °C

To a solution of 5-(ethylthio)pyridin-2-amine (Step A, 1.23 g, 7.96 mmol) in dichloromethane (30 mL) were added trifluoroacetic acid (1.2 mL, 15.9 mmol) and m-chloroperbenzoic acid (4.3 g, 17.5 mmol) at 0° C. The mixture was stirred at 0° C. for 2 h. Aqueous sodium sulfite (20 mL) was added. The mixture was extracted with dichloromethane (30 mL×3) and washed with aqueous sodium hydrogencarbonate (15 mL×2). The organic extracts were dried over sodium sulfate and concentrated to afford the title compound (1.43 g, 97%) as a white solid.

1. extractionThe mixture was extracted with dichloromethane (30 mL×3)
2. washwashed with aqueous sodium hydrogencarbonate (15 mL×2)
3. dry with materialThe organic extracts were dried over sodium sulfate
4. concentrationconcentrated