Hydrochloric Acid → HCID 68869381, compound

HRID 1817881Notes

Reaction equation

HRID 1817881 reaction equation
[C:1]([C:5]1[N:9]([CH2:10][CH:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[C:8]2[CH:17]=[CH:18][C:19]([S:21]([CH2:24][CH3:25])(=[O:23])=[O:22])=[CH:20][C:7]=2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:26]>C(OCC)(=O)C>[ClH:26].[C:1]([C:5]1[N:9]([CH2:10][CH:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[C:8]2[CH:17]=[CH:18][C:19]([S:21]([CH2:24][CH3:25])(=[O:23])=[O:22])=[CH:20][C:7]=2[N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44448413HCID 44448413, compound

Product 1

HCID 68869381HCID 68869381, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 2-tert-butyl-5-(ethylsulfonyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazole (Step A, 113 mg, 0.31 mmol) in ethyl acetate (3 mL) was added 4 N hydrogen chloride in ethyl acetate (1 mL). The mixture was concentrated and the residue was recrystalized from ethyl acetate and methanol to afford the title compound (92.5 mg, 0.23 mmol, 74%) as a white solid.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was recrystalized from ethyl acetate and methanol

Sources & evidence

ORD record
ord-bd91243188b74006b6b1db50f5e5f6a2
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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