反应详情

Methyl bromoacetate (367 mg, 2.4 mmol) was added to a stirred mixture of 8-hydroxy-1H-quinolin-2-one [which was prepared according to literature procedure (Wang, T. C. et al, Synthesis, 1997, 87-90)], (322 mg, 2 mmol), K2CO3 (414 mg, 3 mmol) in DMF (10 ml) at room temperature. The reaction mixture was stirred at rt over night and then partitioned between dichloromethane and water. Water layer was extracted with dichloromethane (2×50 ml). The combined organic phase was washed with water (3×50 ml), brine and dried over sodium sulfate. After removal of solvent, the residue was washed with ether to give 250 mg of compound I-71.

1. custompartitioned between dichloromethane and water
2. extractionWater layer was extracted with dichloromethane (2×50 ml)
3. washThe combined organic phase was washed with water (3×50 ml), brine
4. dry with materialdried over sodium sulfate
5. customAfter removal of solvent
6. washthe residue was washed with ether