8-Fluoro-1-benzosuberone → HCID 22391779, compound

HRID 1818028Notes

Reaction equation

HRID 1818028 reaction equation
[F:1][C:2]1[CH:13]=[CH:12][C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][C:10](=O)[C:4]=2[CH:3]=1.[BH3-]C#[N:16].[Na+]>C(O)(C)C>[F:1][C:2]1[CH:13]=[CH:12][C:5]2[CH2:6][CH2:7][CH2:8][CH2:9][CH:10]([NH2:16])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 5790508-Fluoro-1-benzosuberoneHCID 5003444Sodium cyanoborohydride

Product 1

HCID 22391779HCID 22391779, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3-Fluoro-6,7,8,9-tetrahydro-benzocyclohepten-5-one (5.00 g, 28.00 mmol), NaBH3CN (12.50 g, 0.20 mol) and NH4OAc (65.00 g, 0.84 mol) in isopropanol were reacted according to the protocols as outlined in general procedure C to afford the title amine.

Sources & evidence

ORD record
ord-86085947ba6d4e45ac1f151fab51f8f4
Source dataset
uspto-grants-2009_10
Patent number
US07598417B2

Reaction notes

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