Water → HCID 10215509, compound

HRID 1818062Notes

Reaction equation

HRID 1818062 reaction equation
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9]([S:15](Cl)(=[O:17])=[O:16])=[CH:10]2)(=[O:3])[CH3:2].[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(N(CC)CC)C.O>O1CCCC1>[C:1]([NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9]([S:15]([NH:26][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)(=[O:17])=[O:16])=[CH:10]2)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 7504BenzylamineHCID 8471TriethylamineHCID 18766073HCID 18766073, compound

Product 1

HCID 10215509HCID 10215509, compoundYield 84.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(Acetylamino)naphthalene-2-sulfonyl chloride (280 mg, 0.987 mmol) was added to benzylamine (127 mg, 1.19 mmol) and triethylamine (0.17 ml, 1.22 mmol) dissolved in tetrahydrofuran (3.0 ml), and the mixture was stirred at room temperature for 1 hour. Water (10 ml) was added to the reaction solution, and after the mixture was stirred for 10 minutes, the resulting solid was collected. The solid was washed with water and isopropyl ether to give the title compound as a light pink solid (296 mg, 84.6%).

Workup

  1. stirringafter the mixture was stirred for 10 minutes
  2. customthe resulting solid was collected
  3. washThe solid was washed with water and isopropyl ether

Sources & evidence

ORD record
ord-73ac0a4a0c474a528052e85f6d31e2db
Source dataset
uspto-grants-2009_10
Patent number
US07598418B2

Reaction notes

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