反应详情

To a solution of 2-chloro-5-nitro-4-thiocyanatopyrimidine (1 g, 4.6 mmol) in DMF (5 mL) was added 2-(trifluoromethoxy)benzylamine (883 mg, 4.6 mmol) followed by DIPEA (804 μL, 4.6 mmol). The reaction mixture was stirred at room temperature for 30 min and diluted with EtOAc. The solution was washed with water (×4). The organic phase was dried over anhydrous Na2SO4 and then concentrated in vacuo. The resulting residue was purified by silica gel prep TLC using CH2Cl2 as an eluent to afford 727 mg (42%) of the desired product as a yellowish solid.

1. washThe solution was washed with water (×4)
2. dry with materialThe organic phase was dried over anhydrous Na2SO4
3. concentrationconcentrated in vacuo
4. customThe resulting residue was purified by silica gel prep TLC