1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 68681774, compound

HRID 1820557Notes

Reaction equation

HRID 1820557 reaction equation
[CH3:1][N:2]([CH3:26])[CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([C:9]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[N:16]([CH:20]([CH3:22])[CH3:21])[C:15]([C:23]([OH:25])=O)=[CH:14]3)=[O:10])[CH2:4]1.Cl.[F:28][C:29]1([F:35])[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1.Cl.C(N=C=NCCCN(C)C)C>C(N(CC)CC)C>[F:28][C:29]1([F:35])[CH2:34][CH2:33][N:32]([C:23]([C:15]2[N:16]([CH:20]([CH3:21])[CH3:22])[C:17]3[C:13]([CH:14]=2)=[CH:12][C:11]([C:9]([N:5]2[CH2:6][CH2:7][CH2:8][CH:3]([N:2]([CH3:1])[CH3:26])[CH2:4]2)=[O:10])=[CH:19][CH:18]=3)=[O:25])[CH2:31][CH2:30]1

Participants

5

Reactant 3

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27583514,4-Difluoropiperidine hydrochlorideHCID 68682285HCID 68682285, compound

Product 1

HCID 68681774HCID 68681774, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The title compound was synthesized in analogy to Example 1, from 5-(3-dimethylamino-piperidine-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid, 4,4-difluoropiperidine hydrochloride, triethylamine and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, to afford the product as a light-brown oil (79%).

Sources & evidence

ORD record
ord-fce9b5b43e8149c89e06a1660e26b953
Source dataset
uspto-grants-2009_10
Patent number
US07601711B2

Reaction notes

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