Morpholine → HCID 10388442, compound

HRID 1820686Notes

Reaction equation

HRID 1820686 reaction equation
[C:1]([CH:3]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[O:26][CH3:27])[NH:4][C:5](=[O:19])[C@H:6]([CH2:15][CH:16]([CH3:18])[CH3:17])[NH:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10](F)[N:9]=1)#[N:2].[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1.C(N(CC)C(C)C)(C)C.C(OCC)(=O)C.CCCC(C)C>O1CCCC1>[C:1]([CH:3]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[O:26][CH3:27])[NH:4][C:5](=[O:19])[C@H:6]([CH2:15][CH:16]([CH3:18])[CH3:17])[NH:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)[N:9]=1)#[N:2]

Participants

6

Reactant 4

HCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 21882781Isohexane ethyl acetateHCID 131727666HCID 131727666, compound

Product 1

HCID 10388442HCID 10388442, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product from step (iii) (0.5 g), morpholine (0.12 ml) and N,N-diisopropylethylamine (0.24 ml) in tetrahydrofuran (20 ml) was stirred at room temperature overnight. The solvent was removed under vacuum to yield a crude oil which was subjected to column chromatography on silica eluting with ethyl acetate/isohexane 3:1 to give a white solid (0.4 g).

Workup

  1. customThe solvent was removed under vacuum
  2. customto yield a crude oil which

Sources & evidence

ORD record
ord-5a7ab895927f439d9111df35b4fb5f09
Source dataset
uspto-grants-2009_10
Patent number
US07605159B2

Reaction notes

Loading…