Methylamine → HCID 69042070, compound

HRID 1820820Notes

Reaction equation

[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][C:6]=1[C:14]([N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)[CH2:18][CH2:17]1)=[O:15])([CH3:3])[CH3:2].C1N=C[N:34](C(N2C=NC=C2)=O)[CH:33]=1.CN>CN(C=O)C>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH:34][CH3:33])=[O:10])=[CH:7][C:6]=1[C:14]([N:16]1[CH2:17][CH2:18][N:19]([C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:26][CH:27]=2)[CH2:20][CH2:21]1)=[O:15])([CH3:2])[CH3:3]

Participants

Conditions

Temperature: 50 °C

Procedure

To 0.3 mmol 4-isopropoxy-3-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzoic acid in 2 ml DMF was added 0.4 mmol CDI, and the mixture heated at 50° C. for 30 min. 5.2 mmol methylamine (41% aq solution) was then added, and the mixture was stirred at RT for 16 h. The mixture was then cooled to room temperature, concentrated in vacuo, and the residue chromatographed on silica gel (eluant: ethyl acetate) to afford the title compound. MS (m/e): 450.1 (M+H+, 100%)

Workup

temperatureThe mixture was then cooled to room temperature
concentrationconcentrated in vacuo
customthe residue chromatographed on silica gel (eluant: ethyl acetate)

Sources & evidence

ORD record: ord-46a5b1a7212345fe8f9a43dea23df13e
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07605163B2

Reaction notes

Loading…