反应详情

温度

150 °C

In a microwave reaction tube, 4-chloro-7-azaindole (49, 1.362 g, 8.926 mmol), prepared from 7-azaindole following published procedure (Schneller, S. W.; Luo, Jiann-Kuan. J. Org. Chem. 1980, 45, 4045-4048), 3,4-dimethoxyphenyl boronic acid (4.06 g, 22.3 mmol), and tetrakis(triphenylphosphine)palladium(0) (52 mg, 0.45 mmol) were mixed in 1.0 M potassium carbonate in water (27 mL) and tetrahydrofuran (43 mL). The resulting mixture was heated at 150° C. in a CEM Discover microwave unit for 20 minutes. Ethyl acetate and water were added, and the two layers were separated. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine and dried over anhydrous sodium sulfate. Concentration under reduced pressure afforded the crude material, which was purified by column chromatography (40-70% ethyl acetate in hexane) to yield the desired product in light yellow solid (50, 974 mg, 3.83 mmol). MS(ESI) [M+H+]+=255.2.

1. customthe two layers were separated
2. extractionThe aqueous layer was extracted with ethyl acetate
3. washThe combined organic layers were washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationConcentration under reduced pressure
6. customafforded the crude material, which
7. customwas purified by column chromatography (40-70% ethyl acetate in hexane)