Hydrogen Bromide → HCID 131727673, compound

HRID 1821562Notes

Reaction equation

HRID 1821562 reaction equation
[NH:1]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[C@H:2]([C:4]([NH:6][C@H:7]([C:11]([N:13]1[CH2:20][CH2:19][CH2:18][C@H:14]1[C:15]([OH:17])=O)=[O:12])[CH:8]([CH3:10])[CH3:9])=[O:5])[CH3:3].[CH3:28]N1CCOCC1.[N+](=C)=[N-].[BrH:38]>>[NH:1]([C:21]([O:23][C:24]([CH3:26])([CH3:27])[CH3:25])=[O:22])[C@H:2]([C:4]([NH:6][C@H:7]([C:11]([N:13]1[CH2:20][CH2:19][CH2:18][C@H:14]1[C:15]([CH2:28][Br:38])=[O:17])=[O:12])[CH:8]([CH3:9])[CH3:10])=[O:5])[CH3:3]

Participants

5

Reactant 4

HCID 260Hydrogen BromideHCID 79724-MethylmorpholineHCID 9550DiazomethaneHCID 131727674HCID 131727674, compound

Product 1

HCID 131727673HCID 131727673, compound

Procedure

12 (0.88 g, 2.28 mmol) was treated as described for 13, using CAIBE (2.28 mmol, 0.37 ml), NMM (2.28 mmol, 0.31 ml), diazomethane (14.3 mmol in 15 ml ether) HBr/glacial acetic acid (33%): 4.24 mmol, 1.04 ml.

Sources & evidence

ORD record
ord-2fe28f1fd9f94404865fe729f7e594c5
Source dataset
uspto-grants-2009_10
Patent number
US07608577B2

Reaction notes

Loading…